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Although the presence of dementia and severity of extrapyramidal signs (EPSs)influence morbidity in PD,it is not known whether these manifestations contribute to mortality.Compared with nondemented elderly people in the same community,patients with PD have a 2-to 5-fold increased risk of mortality.The risk is strongly related to the presence of severe EPSs,especially bradykinesia.Despite the introduction of levodopa and other advances in the treatment of PD,these factors greatly increase mortality. |
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